Saporin-S6: A Useful Tool in Cancer Therapy
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چکیده
منابع مشابه
Saporin-S6: A Useful Tool in Cancer Therapy
Thirty years ago, the type 1 ribosome-inactivating protein (RIP) saporin-S6 (also known as saporin) was isolated from Saponaria officinalis L. seeds. Since then, the properties and mechanisms of action of saporin-S6 have been well characterized, and it has been widely employed in the construction of conjugates and immunotoxins for different purposes. These immunotoxins have shown many interesti...
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Ribosome-inactivating proteins (RIPs) are a family of plant toxins that permanently damage ribosomes and possibly other cellular substrates, thus causing cell death. RIPs are mostly divided in two types: Type 1 RIPs that are single-chain enzymatic proteins, and type 2 RIPs that consist of an active A chain (similar to a type 1 RIP) linked to a B chain with lectin properties. RIP-containing conj...
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ژورنال
عنوان ژورنال: Toxins
سال: 2013
ISSN: 2072-6651
DOI: 10.3390/toxins5101698